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Titel:

OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage.

Dokumenttyp:
Journal Article
Autor(en):
Tsvilovskyy, Volodymyr; Ottenheijm, Roger; Kriebs, Ulrich; Schütz, Aline; Diakopoulos, Kalliope Nina; Jha, Archana; Bildl, Wolfgang; Wirth, Angela; Böck, Julia; Jaślan, Dawid; Ferro, Irene; Taberner, Francisco J; Kalinina, Olga; Hildebrand, Staffan; Wissenbach, Ulrich; Weissgerber, Petra; Vogt, Dominik; Eberhagen, Carola; Mannebach, Stefanie; Berlin, Michael; Kuryshev, Vladimir; Schumacher, Dagmar; Philippaert, Koenraad; Camacho-Londoño, Juan E; Mathar, Ilka; Dieterich, Christoph; Klugbauer, Nor...     »
Abstract:
Regulated exocytosis is initiated by increased Ca2+ concentrations in close spatial proximity to secretory granules, which is effectively prevented when the cell is at rest. Here we showed that exocytosis of zymogen granules in acinar cells was driven by Ca2+ directly released from acidic Ca2+ stores including secretory granules through NAADP-activated two-pore channels (TPCs). We identified OCaR1 (encoded by Tmem63a) as an organellar Ca2+ regulator protein integral to the membrane of secretory...     »
Zeitschriftentitel:
J Clin Invest
Jahr:
2024
Band / Volume:
134
Heft / Issue:
7
Volltext / DOI:
doi:10.1172/JCI169428
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38557489
Print-ISSN:
0021-9738
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene (Prof. Göttlicher); Lehrstuhl für Tumormetabolismus (Prof. Algül)
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