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Title:

Thermal Proteome Profiling Reveals Insight to Antiproliferative and Pro-Apoptotic Effects of Lagunamide A in the Modulation of DNA Damage Repair.

Document type:
Journal Article
Author(s):
Hu, Yudong; Mostert, Dietrich; Orgler, Christina; Andler, Oliver; Zischka, Hans; Kazmaier, Uli; Vollmar, Angelika; Braig, Simone; Sieber, Stephan; Zahler, Stefan
Abstract:
Lagunamide A is a biologically active natural product with a yet unidentified molecular mode of action. Cellular studies revealed that lagunamide A is a potent inhibitor of cancer cell proliferation, promotes apoptosis and causes mitochondrial dysfunction. To decipher the cellular mechanism responsible for these effects, we utilized thermal protein profiling (TPP) and identified EYA3 as a stabilized protein in cells upon lagunamide A treatment. EYA3, involved in the DNA damage repair process, wa...     »
Journal title abbreviation:
Chembiochem
Year:
2024
Journal volume:
25
Journal issue:
13
Fulltext / DOI:
doi:10.1002/cbic.202400024
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/38716781
Print-ISSN:
1439-4227
TUM Institution:
Institut für Toxikologie und Umwelthygiene (Prof. Göttlicher)
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