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Titel:

Thermal Proteome Profiling Reveals Insight to Antiproliferative and Pro-Apoptotic Effects of Lagunamide A in the Modulation of DNA Damage Repair.

Dokumenttyp:
Journal Article
Autor(en):
Hu, Yudong; Mostert, Dietrich; Orgler, Christina; Andler, Oliver; Zischka, Hans; Kazmaier, Uli; Vollmar, Angelika; Braig, Simone; Sieber, Stephan; Zahler, Stefan
Abstract:
Lagunamide A is a biologically active natural product with a yet unidentified molecular mode of action. Cellular studies revealed that lagunamide A is a potent inhibitor of cancer cell proliferation, promotes apoptosis and causes mitochondrial dysfunction. To decipher the cellular mechanism responsible for these effects, we utilized thermal protein profiling (TPP) and identified EYA3 as a stabilized protein in cells upon lagunamide A treatment. EYA3, involved in the DNA damage repair process, wa...     »
Zeitschriftentitel:
Chembiochem
Jahr:
2024
Band / Volume:
25
Heft / Issue:
13
Volltext / DOI:
doi:10.1002/cbic.202400024
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38716781
Print-ISSN:
1439-4227
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene (Prof. Göttlicher)
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