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Titel:

Amyotrophic lateral sclerosis associated disturbance of iron metabolism is blunted by swim training-role of AKT signaling pathway.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Halon-Golabek, Małgorzata; Flis, Damian Jozef; Zischka, Hans; Akdogan, Banu; Wieckowski, Mariusz Roman; Antosiewicz, Jedrzej; Ziolkowski, Wiesław
Abstract:
Swim training has increased the life span of the transgenic animal model of amyotrophic lateral sclerosis (ALS). Conversely, the progress of the disease is associated with the impairment of iron metabolism and insulin signaling. We used transgenic hmSOD1 G93A (ALS model) and non-transgenic mice in the present study. The study was performed on the muscles taken from trained (ONSET and TERMINAL) and untrained animals at three stages of the disease: BEFORE, ONSET, and TERMINAL. In order to study th...     »
Zeitschriftentitel:
Biochim Biophys Acta Mol Basis Dis
Jahr:
2024
Band / Volume:
1870
Heft / Issue:
3
Volltext / DOI:
doi:10.1016/j.bbadis.2023.167014
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38171451
Print-ISSN:
0925-4439
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene (Prof. Göttlicher)
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