Benutzer: Gast  Login
Mehr Felder
Einfache Suche
Titel:

IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Dudek, Michael; Lohr, Kerstin; Donakonda, Sainitin; Baumann, Tobias; Lüdemann, Max; Hegenbarth, Silke; Dübbel, Lena; Eberhagen, Carola; Michailidou, Savvoula; Yassin, Abdallah; Prinz, Marco; Popper, Bastian; Rose-John, Stefan; Zischka, Hans; Knolle, Percy A
Abstract:
Liver sinusoidal endothelial cells (LSECs) are liver-resident antigen (cross)-presenting cells that generate memory CD8 T cells, but metabolic properties of LSECs and LSEC-primed CD8 T cells remain understudied. Here, we report that high-level mitochondrial respiration and constitutive low-level glycolysis support LSEC scavenger and sentinel functions. LSECs fail to increase glycolysis and co-stimulation after TLR4 activation, indicating absence of metabolic and functional maturation compared wi...     »
Zeitschriftentitel:
Cell Rep
Jahr:
2022
Band / Volume:
38
Heft / Issue:
7
Volltext / DOI:
doi:10.1016/j.celrep.2022.110389
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35172161
Print-ISSN:
2211-1247
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung; Institut für Toxikologie und Umwelthygiene (Prof. Göttlicher); Roman Herzog Comprehensive Cancer Center
 BibTeX