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Title:

Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling.

Document type:
Article; Journal Article
Author(s):
Xiao, Yan; Petrucco, Luigi; Hoodless, Laura J; Portugues, Ruben; Czopka, Tim
Abstract:
Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid of myelin. Elimination of these OPCs impaired precise control of retinal ganglion cell axon arbor size during formation and maturation of retinotectal connectivity and degraded functional processing of visual stimuli. Therefore, OPCs fine-tune neural circuits independently of their canonical role to make m...     »
Journal title abbreviation:
Nat Neurosci
Year:
2022
Journal volume:
25
Journal issue:
3
Pages contribution:
280-284
Fulltext / DOI:
doi:10.1038/s41593-022-01023-7
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35241802
Print-ISSN:
1097-6256
TUM Institution:
Institut für Neurowissenschaften; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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