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Title:

Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice.

Document type:
Journal Article
Author(s):
Focke, Carola; Blume, Tanja; Zott, Benedikt; Shi, Yuan; Deussing, Maximilian; Peters, Finn; Schmidt, Claudio; Kleinberger, Gernot; Lindner, Simon; Gildehaus, Franz-Josef; Beyer, Leonie; von Ungern-Sternberg, Barbara; Bartenstein, Peter; Ozmen, Laurence; Baumann, Karlheinz; Dorostkar, Mario M; Haass, Christian; Adelsberger, Helmuth; Herms, Jochen; Rominger, Axel; Brendel, Matthias
Abstract:
Neuroinflammation may have beneficial or detrimental net effects on the cognitive outcome of Alzheimer disease (AD) patients. PET imaging with 18-kDa translocator protein (TSPO) enables longitudinal monitoring of microglial activation in vivo. We compiled serial PET measures of TSPO and amyloid with terminal cognitive assessment (water maze) in an AD transgenic mouse model (PS2APP) from 8 to 13 mo of age, followed by immunohistochemical analyses of microglia, amyloid, and synaptic density. Bet...     »
Journal title abbreviation:
J Nucl Med
Year:
2019
Journal volume:
60
Journal issue:
4
Pages contribution:
548-554
Fulltext / DOI:
doi:10.2967/jnumed.118.217703
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30262517
Print-ISSN:
0161-5505
TUM Institution:
Institut für Neurowissenschaften
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