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Title:

Impairments of neural circuit function in Alzheimer's disease.

Document type:
Journal Article; Review; Review
Author(s):
Busche, Marc Aurel; Konnerth, Arthur
Abstract:
An essential feature of Alzheimer's disease (AD) is the accumulation of amyloid-? (A?) peptides in the brain, many years to decades before the onset of overt cognitive symptoms. We suggest that during this very extended early phase of the disease, soluble A? oligomers and amyloid plaques alter the function of local neuronal circuits and large-scale networks by disrupting the balance of synaptic excitation and inhibition (E/I balance) in the brain. The analysis of mouse models of AD revealed that...     »
Journal title abbreviation:
Philos Trans R Soc Lond B Biol Sci
Year:
2016
Journal volume:
371
Journal issue:
1700
Language:
eng
Fulltext / DOI:
doi:10.1098/rstb.2015.0429
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27377723
Print-ISSN:
0962-8436
TUM Institution:
Institut für Neurowissenschaften; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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