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Title:

Microglial activation in the right amygdala-entorhinal-hippocampal complex is associated with preserved spatial learning in AppNL-G-F mice.

Document type:
Journal Article
Author(s):
Biechele, Gloria; Wind, Karin; Blume, Tanja; Sacher, Christian; Beyer, Leonie; Eckenweber, Florian; Franzmeier, Nicolai; Ewers, Michael; Zott, Benedikt; Lindner, Simon; Gildehaus, Franz-Josef; von Ungern-Sternberg, Barbara; Tahirovic, Sabina; Willem, Michael; Bartenstein, Peter; Cumming, Paul; Rominger, Axel; Herms, Jochen; Brendel, Matthias
Abstract:
BACKGROUND: In Alzheimer`s disease (AD), regional heterogeneity of β-amyloid burden and microglial activation of individual patients is a well-known phenomenon. Recently, we described a high incidence of inter-individual regional heterogeneity in terms of asymmetry of plaque burden and microglial activation in β-amyloid mouse models of AD as assessed by positron-emission-tomography (PET). We now investigate the regional associations between amyloid plaque burden, microglial activation, and impai...     »
Journal title abbreviation:
Neuroimage
Year:
2021
Journal volume:
230
Fulltext / DOI:
doi:10.1016/j.neuroimage.2020.117707
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33385560
Print-ISSN:
1053-8119
TUM Institution:
657; Fachgebiet Neuroradiologie (Prof. Zimmer); Institut für Neurowissenschaften
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