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Title:

Notch-mediated re-specification of neuronal identity during central nervous system development.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Engerer, Peter; Petridou, Eleni; Williams, Philip R; Suzuki, Sachihiro C; Yoshimatsu, Takeshi; Portugues, Ruben; Misgeld, Thomas; Godinho, Leanne
Abstract:
Neuronal identity has long been thought of as immutable, so that once a cell acquires a specific fate, it is maintained for life.1 Studies using the overexpression of potent transcription factors to experimentally reprogram neuronal fate in the mouse neocortex2,3 and retina4,5 have challenged this notion by revealing that post-mitotic neurons can switch their identity. Whether fate reprogramming is part of normal development in the central nervous system (CNS) is unclear. While there are some re...     »
Journal title abbreviation:
Curr Biol
Year:
2021
Journal volume:
31
Journal issue:
21
Pages contribution:
4870-4878.e5
Fulltext / DOI:
doi:10.1016/j.cub.2021.08.049
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34534440
Print-ISSN:
0960-9822
TUM Institution:
Institut für Neurowissenschaften; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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