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Title:

Fear learning induces α7-nicotinic acetylcholine receptor-mediated astrocytic responsiveness that is required for memory persistence.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Zhang, Kuan; Förster, Rita; He, Wenjing; Liao, Xiang; Li, Jin; Yang, Chuanyan; Qin, Han; Wang, Meng; Ding, Ran; Li, Ruijie; Jian, Tingliang; Wang, Yanhong; Zhang, Jianxiong; Yang, Zhiqi; Jin, Wenjun; Zhang, Yonghai; Qin, Song; Lu, Yacheng; Chen, Tao; Stobart, Jillian; Weber, Bruno; Adelsberger, Helmuth; Konnerth, Arthur; Chen, Xiaowei
Abstract:
Memory persistence is a fundamental cognitive process for guiding behaviors and is considered to rely mostly on neuronal and synaptic plasticity. Whether and how astrocytes contribute to memory persistence is largely unknown. Here, by using two-photon Ca2+ imaging in head-fixed mice and fiber photometry in freely moving mice, we show that aversive sensory stimulation activates α7-nicotinic acetylcholine receptors (nAChRs) in a subpopulation of astrocytes in the auditory cortex. We demonstrate th...     »
Journal title abbreviation:
Nat Neurosci
Year:
2021
Journal volume:
24
Journal issue:
12
Pages contribution:
1686-1698
Fulltext / DOI:
doi:10.1038/s41593-021-00949-8
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34782794
Print-ISSN:
1097-6256
TUM Institution:
Institut für Neurowissenschaften
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