Benutzer: Gast  Login
Weniger Felder
Einfache Suche
Titel:

Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice.

Dokumenttyp:
Journal Article
Autor(en):
Focke, Carola; Blume, Tanja; Zott, Benedikt; Shi, Yuan; Deussing, Maximilian; Peters, Finn; Schmidt, Claudio; Kleinberger, Gernot; Lindner, Simon; Gildehaus, Franz-Josef; Beyer, Leonie; von Ungern-Sternberg, Barbara; Bartenstein, Peter; Ozmen, Laurence; Baumann, Karlheinz; Dorostkar, Mario M; Haass, Christian; Adelsberger, Helmuth; Herms, Jochen; Rominger, Axel; Brendel, Matthias
Abstract:
Neuroinflammation may have beneficial or detrimental net effects on the cognitive outcome of Alzheimer disease (AD) patients. PET imaging with 18-kDa translocator protein (TSPO) enables longitudinal monitoring of microglial activation in vivo. We compiled serial PET measures of TSPO and amyloid with terminal cognitive assessment (water maze) in an AD transgenic mouse model (PS2APP) from 8 to 13 mo of age, followed by immunohistochemical analyses of microglia, amyloid, and synaptic density. Bet...     »
Zeitschriftentitel:
J Nucl Med
Jahr:
2019
Band / Volume:
60
Heft / Issue:
4
Seitenangaben Beitrag:
548-554
Volltext / DOI:
doi:10.2967/jnumed.118.217703
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30262517
Print-ISSN:
0161-5505
TUM Einrichtung:
Institut für Neurowissenschaften
 BibTeX