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Titel:

High-performance calcium sensors for imaging activity in neuronal populations and microcompartments.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Dana, Hod; Sun, Yi; Mohar, Boaz; Hulse, Brad K; Kerlin, Aaron M; Hasseman, Jeremy P; Tsegaye, Getahun; Tsang, Arthur; Wong, Allan; Patel, Ronak; Macklin, John J; Chen, Yang; Konnerth, Arthur; Jayaraman, Vivek; Looger, Loren L; Schreiter, Eric R; Svoboda, Karel; Kim, Douglas S
Abstract:
Calcium imaging with genetically encoded calcium indicators (GECIs) is routinely used to measure neural activity in intact nervous systems. GECIs are frequently used in one of two different modes: to track activity in large populations of neuronal cell bodies, or to follow dynamics in subcellular compartments such as axons, dendrites and individual synaptic compartments. Despite major advances, calcium imaging is still limited by the biophysical properties of existing GECIs, including affinity,...     »
Zeitschriftentitel:
Nat Methods
Jahr:
2019
Band / Volume:
16
Heft / Issue:
7
Seitenangaben Beitrag:
649-657
Volltext / DOI:
doi:10.1038/s41592-019-0435-6
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31209382
Print-ISSN:
1548-7091
TUM Einrichtung:
Institut für Neurowissenschaften
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