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Titel:

cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium.

Dokumenttyp:
Journal Article
Autor(en):
Wang, Rui; Islam, Bianca N; Bridges, Allison; Sharman, Sarah K; Hu, Muhan; Hou, Yali; Somanath, Payaningal R; Venable, Laine; Singh, Nagendra; Kim, Sangmi; Sridhar, Subbaramiah; Hofmann, Franz; Browning, Darren D
Abstract:
Signaling through cGMP has therapeutic potential in the colon, where it has been implicated in the suppression of colitis and colon cancer. In this study, we tested the ability of cGMP and type 2 cGMP-dependent protein kinase (PKG2) to activate forkhead box O (FoxO) in colon cancer cells and in the colon epithelium of mice. We show that activation of PKG2 in colon cancer cells inhibited cell proliferation, inhibited AKT, and activated FoxO. Treatment of colon explants with 8Br-cGMP also activate...     »
Zeitschriftentitel:
Am J Pathol
Jahr:
2017
Band / Volume:
187
Heft / Issue:
2
Seitenangaben Beitrag:
377-389
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.ajpath.2016.10.016
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27998725
Print-ISSN:
0002-9440
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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