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Titel:

Two serines in the distal C-terminus of the human ß1-adrenoceptor determine ß-arrestin2 recruitment.

Dokumenttyp:
Journal Article
Autor(en):
Hinz, Laura; Ahles, Andrea; Ruprecht, Benjamin; Kuster, Bernhard; Engelhardt, Stefan
Abstract:
G protein-coupled receptors (GPCRs) undergo phosphorylation at several intracellular residues by G protein-coupled receptor kinases. The resulting phosphorylation pattern triggers arrestin recruitment and receptor desensitization. The exact sites of phosphorylation and their function remained largely unknown for the human ?1-adrenoceptor (ADRB1), a key GPCR in adrenergic signal transduction and the target of widely used drugs such as ?-blockers. The present study aimed to identify the intracellu...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2017
Band / Volume:
12
Heft / Issue:
5
Seitenangaben Beitrag:
e0176450
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0176450
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28472170
Print-ISSN:
1932-6203
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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