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Titel:

Inhibition of the TGF? signalling pathway by cGMP and cGMP-dependent kinase I in renal fibrosis.

Dokumenttyp:
Journal Article
Autor(en):
Schinner, Elisabeth; Wetzl, Veronika; Schramm, Andrea; Kees, Frieder; Sandner, Peter; Stasch, Johannes-Peter; Hofmann, Franz; Schlossmann, Jens
Abstract:
Agents that enhance production of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) ameliorate the progression of renal fibrosis. However, the molecular mechanism of this process is not fully understood. We hypothesize that the antifibrotic effects of cGMP and cGMP-dependent kinase I (cGKI) are mediated via regulation of the TGF? signalling pathway, both via ERK and the Smad-dependent route. Kidney fibrosis was induced by unilateral ureter obstruction (UUO) in wild-type and cGKI-defici...     »
Zeitschriftentitel:
FEBS Open Bio
Jahr:
2017
Band / Volume:
7
Heft / Issue:
4
Seitenangaben Beitrag:
550-561
Sprache:
eng
Volltext / DOI:
doi:10.1002/2211-5463.12202
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28396839
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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