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Titel:

CXCR4 hyperactivation cooperates with TCL1 in CLL development and aggressiveness.

Dokumenttyp:
Journal Article
Autor(en):
Lewis, Richard; Maurer, H Carlo; Singh, Nikita; Gonzalez-Menendez, Irene; Wirth, Matthias; Schick, Markus; Zhang, Le; Isaakidis, Konstandina; Scherger, Anna Katharina; Schulze, Veronika; Lu, Junyan; Zenz, Thorsten; Steiger, Katja; Rad, Roland; Quintanilla-Martinez, Leticia; Espeli, Marion; Balabanian, Karl; Keller, Ulrich; Habringer, Stefan
Abstract:
Aberrant CXCR4 activity has been implicated in lymphoma pathogenesis, disease progression, and resistance to therapies. Using a mouse model with a gain-of-function CXCR4 mutation (CXCR4C1013G) that hyperactivates CXCR4 signaling, we identified CXCR4 as a crucial activator of multiple key oncogenic pathways. CXCR4 hyperactivation resulted in an expansion of transitional B1 lymphocytes, which represent the precursors of chronic lymphocytic leukemia (CLL). Indeed, CXCR4 hyperactivation led to a sig...     »
Zeitschriftentitel:
Leukemia
Jahr:
2021
Band / Volume:
35
Heft / Issue:
10
Seitenangaben Beitrag:
2895-2905
Volltext / DOI:
doi:10.1038/s41375-021-01376-1
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34363012
Print-ISSN:
0887-6924
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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