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Title:

Decision impact and feasibility of different ASCO-recommended biomarkers in early breast cancer: Prospective comparison of molecular marker EndoPredict and protein marker uPA/PAI-1.

Document type:
Comparative Study; Journal Article
Author(s):
Ettl, Johannes; Klein, Evelyn; Hapfelmeier, Alexander; Grosse Lackmann, Kirsten; Paepke, Stefan; Petry, Christoph; Specht, Katja; Wolff, Laura; Höfler, Heinz; Kiechle, Marion
Abstract:
Adjuvant therapy decisions in early breast cancer are based on accurate risk assessment. Urokinase plasminogen activator (uPA) and plaminogen activator inhibitor-1 (PAI-1) have been the first biomarkers in hormone receptor (HR) positive breast cancer to reach highest level of evidence. The EndoPredict test (EPclin) combines gene expression information with nodal status and tumor size. The aim of this prospective study was to compare uPA/PAI-1 and EPclin as prognostic biomarkers with regard to fe...     »
Journal title abbreviation:
PLoS ONE
Year:
2017
Journal volume:
12
Journal issue:
9
Pages contribution:
e0183917
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0183917
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28877230
Print-ISSN:
1932-6203
TUM Institution:
Frauenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie
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