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Titel:

Presentation of a Conserved Adenoviral Epitope on HLA-C*0702 Allows Evasion of Natural Killer but Not T Cell Responses.

Dokumenttyp:
Journal Article; Article
Autor(en):
Keib, Anna; Günther, Patrick S; Faist, Benjamin; Halenius, Anne; Busch, Dirk H; Neuenhahn, Michael; Jahn, Gerhard; Dennehy, Kevin M
Abstract:
Infection with adenovirus is a major cause of infectious mortality in children following hematopoietic stem-cell transplantation. While adoptive transfer of epitope-specific T cells is a particularly effective therapeutic approach, there are few suitable adenoviral peptide epitopes described to date. Here, we describe the adenoviral peptide epitope FRKDVNMVL from hexon protein, and its variant FRKDVNMIL, that is restricted by human leukocyte antigen (HLA)-C*0702. Since HLA-C*0702 can be recogniz...     »
Zeitschriftentitel:
Viral Immunol
Jahr:
2017
Band / Volume:
30
Heft / Issue:
3
Seitenangaben Beitrag:
149-156
Sprache:
eng
Volltext / DOI:
doi:10.1089/vim.2016.0145
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28085643
Print-ISSN:
0882-8245
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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