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Titel:

Lymphodepletion - an essential but undervalued part of the chimeric antigen receptor T-cell therapy cycle.

Dokumenttyp:
Journal Article; Review; Research Support, Non-U.S. Gov't
Autor(en):
Lickefett, Benno; Chu, Lulu; Ortiz-Maldonado, Valentin; Warmuth, Linda; Barba, Pere; Doglio, Matteo; Henderson, David; Hudecek, Michael; Kremer, Andreas; Markman, Janet; Nauerth, Magdalena; Negre, Helene; Sanges, Carmen; Staber, Philipp B; Tanzi, Rebecca; Delgado, Julio; Busch, Dirk H; Kuball, Jürgen; Luu, Maik; Jäger, Ulrich
Abstract:
Lymphodepletion (LD) or conditioning is an essential step in the application of currently used autologous and allogeneic chimeric antigen receptor T-cell (CAR-T) therapies as it maximizes engraftment, efficacy and long-term survival of CAR-T. Its main modes of action are the depletion and modulation of endogenous lymphocytes, conditioning of the microenvironment for improved CAR-T expansion and persistence, and reduction of tumor load. However, most LD regimens provide a broad and fairly unspeci...     »
Zeitschriftentitel:
Front Immunol
Jahr:
2023
Band / Volume:
14
Volltext / DOI:
doi:10.3389/fimmu.2023.1303935
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38187393
Print-ISSN:
1664-3224
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene (Prof. Busch)
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