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Title:

Isotope tracing reveals bacterial catabolism of host-derived glutathione during Helicobacter pylori infection.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Author(s):
Baskerville, Maia J; Kovalyova, Yekaterina; Mejías-Luque, Raquel; Gerhard, Markus; Hatzios, Stavroula K
Abstract:
Mammalian cells synthesize the antioxidant glutathione (GSH) to shield cellular biomolecules from oxidative damage. Certain bacteria, including the gastric pathogen Helicobacter pylori, can perturb host GSH homeostasis. H. pylori infection significantly decreases GSH levels in host tissues, which has been attributed to the accumulation of reactive oxygen species in infected cells. However, the precise mechanism of H. pylori-induced GSH depletion remains unknown, and tools for studying this proce...     »
Journal title abbreviation:
PLoS Pathog
Year:
2023
Journal volume:
19
Journal issue:
7
Fulltext / DOI:
doi:10.1371/journal.ppat.1011526
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37494402
Print-ISSN:
1553-7366
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene (Prof. Busch)
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