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Title:

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Xie, Kan; Neff, Frauke; Markert, Astrid; Rozman, Jan; Aguilar-Pimentel, Juan Antonio; Amarie, Oana Veronica; Becker, Lore; Brommage, Robert; Garrett, Lillian; Henzel, Kristin S; Hölter, Sabine M; Janik, Dirk; Lehmann, Isabelle; Moreth, Kristin; Pearson, Brandon L; Racz, Ildiko; Rathkolb, Birgit; Ryan, Devon P; Schröder, Susanne; Treise, Irina; Bekeredjian, Raffi; Busch, Dirk H; Graw, Jochen; Ehninger, Gerhard; Klingenspor, Martin; Klopstock, Thomas; Ollert, Markus; Sandholzer, Michael; Schmidt-W...     »
Abstract:
Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in these animals. We compare more than 200 phenotypes in over 20 tissues in aged animals fed with a lifelong every-other-day feeding or ad libitum access to food diet to determine whether molecular, cellular, physiological and histopathological aging feat...     »
Journal title abbreviation:
Nat Commun
Year:
2017
Journal volume:
8
Journal issue:
1
Pages contribution:
155
Language:
eng
Fulltext / DOI:
doi:10.1038/s41467-017-00178-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28761067
Print-ISSN:
2041-1723
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Molekulare Allergologie (Prof. Schmidt-Weber)
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