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Title:

Recruitment of epitope-specific T cell clones with a low-avidity threshold supports efficacy against mutational escape upon re-infection.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Straub, Adrian; Grassmann, Simon; Jarosch, Sebastian; Richter, Lena; Hilgendorf, Philipp; Hammel, Monika; Wagner, Karolin I; Buchholz, Veit R; Schober, Kilian; Busch, Dirk H
Abstract:
Repetitive pathogen exposure leads to the dominant outgrowth of T cell clones with high T cell receptor (TCR) affinity to the relevant pathogen-associated antigens. However, low-affinity clones are also known to expand and form immunological memory. While these low-affinity clones contribute less immunity to the original pathogen, their role in protection against pathogens harboring immune escape mutations remains unclear. Based on identification of the TCR repertoire and functionality landscape...     »
Journal title abbreviation:
Immunity
Year:
2023
Journal volume:
56
Journal issue:
6
Pages contribution:
1269-1284.e6
Fulltext / DOI:
doi:10.1016/j.immuni.2023.04.010
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37164014
Print-ISSN:
1074-7613
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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