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Title:

Ewing sarcoma partial regression without GvHD by chondromodulin-I/HLA-A*02:01-specific allorestricted T cell receptor transgenic T cells.

Document type:
Journal Article; Article
Author(s):
Thiel, Uwe; Schober, Sebastian J; Einspieler, Ingo; Kirschner, Andreas; Thiede, Melanie; Schirmer, David; Gall, Katja; Blaeschke, Franziska; Schmidt, Oxana; Jabar, Susanne; Ranft, Andreas; Alba Rubio, Rebeca; Dirksen, Uta; Grünewald, Thomas G P; Sorensen, Poul H; Richter, Günther H S; von Lüttichau, Irene Teichert; Busch, Dirk H; Burdach, Stefan E G
Abstract:
Background: Chondromodulin-I (CHM1) sustains malignancy in Ewing sarcoma (ES). Refractory ES carries a dismal prognosis and patients with bone marrow (BM) metastases do not survive irrespective of therapy. We assessed HLA-A*02:01/CHM1-specific allorestricted T cell receptor (TCR) wild-type and transgenic cytotoxic (CD8+) T cells against ES. Patients and Methods: Three refractory HLA-A2+ ES patients were treated with HLA-A*02:01/peptide-specific allorepertoire-derived (i.e., allorestricted) CD8+...     »
Journal title abbreviation:
Oncoimmunology
Year:
2017
Journal volume:
6
Journal issue:
5
Pages contribution:
e1312239
Language:
eng
Fulltext / DOI:
doi:10.1080/2162402X.2017.1312239
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28638739
Print-ISSN:
2162-4011
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin; Klinik und Poliklinik für Nuklearmedizin
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