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Title:

Helicobacter pylori promotes colorectal carcinogenesis by deregulating intestinal immunity and inducing a mucus-degrading microbiota signature.

Document type:
Journal Article
Author(s):
Ralser, Anna; Dietl, Alisa; Jarosch, Sebastian; Engelsberger, Veronika; Wanisch, Andreas; Janssen, Klaus Peter; Middelhoff, Moritz; Vieth, Michael; Quante, Michael; Haller, Dirk; Busch, Dirk H; Deng, Li; Mejías-Luque, Raquel; Gerhard, Markus
Abstract:
OBJECTIVE: Helicobacter pylori infection is the most prevalent bacterial infection worldwide. Besides being the most important risk factor for gastric cancer development, epidemiological data show that infected individuals harbour a nearly twofold increased risk to develop colorectal cancer (CRC). However, a direct causal and functional connection between H. pylori infection and colon cancer is lacking. DESIGN: We infected two Apc-mutant mouse models and C57BL/6 mice with H. pylori and conducted...     »
Journal title abbreviation:
Gut
Year:
2023
Journal volume:
72
Journal issue:
7
Pages contribution:
1258-1270
Fulltext / DOI:
doi:10.1136/gutjnl-2022-328075
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37015754
Print-ISSN:
0017-5749
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene (Prof. Busch); Klinik und Poliklinik für Chirurgie (Prof. Friess); Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid)
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