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Titel:

Chemokine fractalkine mediates leukocyte recruitment to inflammatory endothelial cells in flowing whole blood: a critical role for P-selectin expressed on activated platelets.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Schulz, C; Schafer, A; Stolla, M; Kerstan, S; Lorenz, M; von Brühl, ML; Schiemann, M; Bauersachs, J; Gloe, T; Busch, DH; Gawaz, M; Massberg, S
Abstract:
BACKGROUND: The membrane-bound chemokine fractalkine (CX3CL1) is expressed on various cell types such as activated endothelial cells and has been implicated in the inflammatory process of atherosclerosis. The aim of the present study was to dissect the role of fractalkine in leukocyte recruitment to inflamed endothelium under arterial shear forces. METHODS AND RESULTS: With the use of immunofluorescence and laminar flow assays, the present study shows that human umbilical vein endothelial cells...     »
Zeitschriftentitel:
Circulation
Jahr:
2007
Band / Volume:
116
Heft / Issue:
7
Seitenangaben Beitrag:
764-73
Sprache:
eng
Volltext / DOI:
doi:10.1161/CIRCULATIONAHA.107.695189
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17679613
Print-ISSN:
0009-7322
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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