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Title:

Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques.

Document type:
Journal Article; Article
Author(s):
Burwitz, Benjamin J; Wettengel, Jochen M; Mück-Häusl, Martin A; Ringelhan, Marc; Ko, Chunkyu; Festag, Marvin M; Hammond, Katherine B; Northrup, Mina; Bimber, Benjamin N; Jacob, Thomas; Reed, Jason S; Norris, Reed; Park, Byung; Moller-Tank, Sven; Esser, Knud; Greene, Justin M; Wu, Helen L; Abdulhaqq, Shaheed; Webb, Gabriela; Sutton, William F; Klug, Alex; Swanson, Tonya; Legasse, Alfred W; Vu, Tania Q; Asokan, Aravind; Haigwood, Nancy L; Protzer, Ulrike; Sacha, Jonah B
Abstract:
Hepatitis B virus (HBV) is a major global health concern, and the development of curative therapeutics is urgently needed. Such efforts are impeded by the lack of a physiologically relevant, pre-clinical animal model of HBV infection. Here, we report that expression of the HBV entry receptor, human sodium-taurocholate cotransporting polypeptide (hNTCP), on macaque primary hepatocytes facilitates HBV infection in vitro, where all replicative intermediates including covalently closed circular DNA...     »
Journal title abbreviation:
Nat Commun
Year:
2017
Journal volume:
8
Journal issue:
1
Pages contribution:
2146
Language:
eng
Fulltext / DOI:
doi:10.1038/s41467-017-01953-y
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29247188
Print-ISSN:
2041-1723
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Virologie
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