The Wnt/beta-catenin pathway plays an important role in gastrointestinal development, homeostasis, and carcinogenesis. In a conditional mouse model, intestine-specific knockout of Wnt target gene Sox17 was irrelevant for development and homeostasis of intestinal epithelium. In situ hybridizations for Axin2 and Olfm4 demonstrated the involvement of Wnt signaling in acute intestinal perturbation in two mouse models. In gastric cancer, RNF43 was upregulated and localized (peri-)nuclear but did not suppress Wnt signaling.     «

The Wnt/beta-catenin pathway plays an important role in gastrointestinal development, homeostasis, and carcinogenesis. In a conditional mouse model, intestine-specific knockout of Wnt target gene Sox17 was irrelevant for development and homeostasis of intestinal epithelium. In situ hybridizations for Axin2 and Olfm4 demonstrated the involvement of Wnt signaling in acute intestinal perturbation in two mouse models. In gastric cancer, RNF43 was upregulated and localized (peri-)nuclear but did not...     »