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- Original title:
- Insulin signaling regulates localization and translation of Pink1 mRNA via modulation of AMPK activity to support mitophagy in neurons
- Translated title:
- Insulin reguliert die Lokalisierung und Translation von Pink1 mRNA durch Modulation von AMPK Aktivität und fördert Mitophagie in Neuronen
- Author:
- Hees, Jara Tabitha
- Year:
- 2024
- Document type:
- Dissertation
- Faculty/School:
- TUM School of Medicine and Health
- Institution:
- Professur für Neurons and Metabolism (Prof. Harbauer)
- Advisor:
- Harbauer, Angelika (Prof. Dr.)
- Referee:
- Harbauer, Angelika (Prof. Dr.); Nedialkova, Danny (Prof. Dr.); Winklhofer, Konstanze (Prof. Dr. Dr.)
- Language:
- en
- Subject group:
- MED Medizin
- Keywords:
- neurons ; mitochondria ; mitophagy ; PINK1 ; RNA transport ; insulin ; AMPK ; SYNJ2BP ; ApoE4 ; Alzheimer’s disease
- Translated keywords:
- Neuronen ; Mitochondrien ; Mitophagie ; PINK1 ; RNA transport ; Insulin ; AMPK ; SYNJ2BP ; ApoE4 ; Alzheimer
- TUM classification:
- CHE 801; BIO 781
- Abstract:
- Neurons’ extended structure challenges mitochondrial maintenance. PINK1-mediated mitophagy prevents accumulation of defective mitochondria, vital to prevent neurodegeneration. Pink1 mRNA travels with mitochondria via SYNJ2BP/SYNJ2 allowing for on-demand local translation. AMPK phosphorylates SYNJ2BP at S21. Insulin-mediated inhibition of AMPK reduces mitochondrial Pink1 mRNA tethering, which increases its translation and promotes mitophagy. ApoE4-induced insulin resistance disrupts PINK1, linkin... »
- Translated abstract:
- Die komplexe Struktur von Neuronen stellt eine Herausforderung für die Erhaltung von Mitochondrien dar. PINK1-abhängige Mitophagie verhindert die Ansammlung defekter Mitochondrien. Pink1 mRNA wird mit Mitochondrien mittels SYNJ2BP/SYNJ2 transportiert, was lokale Translation ermöglicht. AMPK phosphoryliert SYNJ2BP an S21. Insulin inhibiert AMPK, was die Bindung von Pink1 mRNA an Mitochondrien reduziert, Translation erhöht und Mitophagie fördert. ApoE4-bedingte Insulinresistenz stört PINK1 und ver... »
- WWW:
- https://mediatum.ub.tum.de/?id=1718772
- Date of submission:
- 09.11.2023
- Oral examination:
- 08.07.2024
- File size:
- 7981812 bytes
- Pages:
- 138
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20240708-1718772-1-9
- Last change:
- 08.08.2024
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