Krebszellen können der gegen sie gerichteten Immunantwort entgehen, indem sie Immuncheckpointmolekülen wie PD-L1 auf ihrer Oberfläche präsentieren. Der Transkriptionsfaktor c-MYC spielt in der Pathogenese von aggressiven B-Zell-Lymphomen eine wichtige Rolle. Wir konnten zeigen, dass MYC(+) B-NHL eine verminderte Expression von Immuncheckpointmolekülen aufweisen. Außerdem liefern wir Hinweise darauf, dass MYC in einer humanen Lymphomzelllinie die Expression von PD-L1 negativ reguliert.
Übersetzte Kurzfassung:
Many cancer cells acquire mechanisms to escape the host immune system for example by presenting immune checkpoint molecules such as PD-L1 on the cell surface. The transcription factor MYC plays an essential role in the pathogenesis of aggressive B-cell non hodgkin lymphomas (NHL). We demonstrate that MYC(+) B-cell NHL show a reduced expression of immune checkpoint molecules. Furthermore, we provide evidence that MYC can negatively regulate PD-L1 expression in a MYC-inducible human lymphoma cell line.
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Many cancer cells acquire mechanisms to escape the host immune system for example by presenting immune checkpoint molecules such as PD-L1 on the cell surface. The transcription factor MYC plays an essential role in the pathogenesis of aggressive B-cell non hodgkin lymphomas (NHL). We demonstrate that MYC(+) B-cell NHL show a reduced expression of immune checkpoint molecules. Furthermore, we provide evidence that MYC can negatively regulate PD-L1 expression in a MYC-inducible human lymphoma cell...
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