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Original title:
Computational analysis and prediction of protein interaction sites in transmembrane proteins
Translated title:
Computeranalyse und Vorhersage von Proteinen Interaktionsstellen in Transmembranproteinen
Author:
Zeng, Bo
Year:
2019
Document type:
Dissertation
Faculty/School:
Fakultät Wissenschaftszentrum Weihenstephan
Advisor:
Frishman, Dmitrij (Prof. Dr.)
Referee:
Frishman, Dmitrij (Prof. Dr.); Langosch, Dieter (Prof. Dr.)
Language:
en
Subject group:
BIO Biowissenschaften
TUM classification:
BIO 110d
Abstract:
Alpha-helical membrane proteins are vital for many biological processes, sequence-based interaction sites prediction tools are highly motivated for membrane protein structure prediction, mutagenesis, and better small molecular drug design. In this study, we created the Transmembrane HOmodimer Interface Prediction Algorithm (THOIPA) for single-pass membrane proteins, and MBPred (Membrane Binding-site Prediction) for the interfacial residues prediction of alpha-helical membrane proteins. These two...     »
Translated abstract:
Alpha-helikale Membranproteine sind für viele biologische Prozesse lebenswichtig, sequenzbasierte Interaktionsstellen-Vorhersagewerkzeuge sind hoch motiviert für die Vorhersage von Membranproteinstrukturen, Mutagenese und ein besseres kleinmolekulares Wirkstoffdesign. In dieser Studie haben wir den Transmembran HOmodimer Interface Prediction Algorithm (THOIPA) für Single-Pass-Membranproteine und MBPred (Membrane Binding-site Prediction) für die Vorhersage von Grenzflächenrückständen von alpha-he...     »
WWW:
https://mediatum.ub.tum.de/?id=1468889
Date of submission:
17.12.2018
Oral examination:
24.04.2019
File size:
7084396 bytes
Pages:
153
Urn (citeable URL):
https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20190424-1468889-1-9
Last change:
06.05.2019
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