1. Structural and Mechanistic Characterization of a Type II Polyketide Synthase involved in Anthraquinone Biosynthesis 2. Structural and Mechanistic Characterization of the FeII/α-Ketoglutarate-dependent Dioxygenase AsqJ
Translated title:
1. Strukturelle und mechanistische Charakterisierung einer Typ II-Polyketidsynthase für die Biosynthese von Anthrachinonen 2. Strukturelle und mechanistische Charakterisierung der FeII/α-Ketoglutarat-abhängigen Dioxygenase AsqJ
Author:
Bräuer, Alois
Year:
2018
Document type:
Dissertation
Faculty/School:
Fakultät für Chemie
Advisor:
Groll, Michael (Prof. Dr.)
Referee:
Groll, Michael (Prof. Dr.); Gulder, Tobias A. M. (Prof. Dr.)
Language:
en
Subject group:
CHE Chemie
TUM classification:
CHE 800d
Abstract:
Biosynthetic pathways are nature’s route maps to diverse classes of natural products and an understanding of these pathways is crucial for the discovery of new and effective medicines to combat disease and overcome drug resistance. This thesis gives structural and mechanistic insights into the logic of type II polyketide synthases (PKSs) at the level of protein-protein interactions and into a member of the key tailoring and maturation catalysts in all natural product classes, namely oxygenases, both of vital importance for fundamental enzymology and medicinal purposes.
«
Biosynthetic pathways are nature’s route maps to diverse classes of natural products and an understanding of these pathways is crucial for the discovery of new and effective medicines to combat disease and overcome drug resistance. This thesis gives structural and mechanistic insights into the logic of type II polyketide synthases (PKSs) at the level of protein-protein interactions and into a member of the key tailoring and maturation catalysts in all natural product classes, namely oxygenases,...
»
Translated abstract:
Ein Verständnis der Biosynthesewege von Naturstoffen ist von großer Bedeutung, um neue und effektive Wirkstoffe gegen Krankheiten zu entdecken und Wirkstoffresistenzen zu bekämpfen. Die vorliegende Arbeit gibt strukturelle und mechanistische Einblicke in die Logik von Typ II-Polyketidsynthasen (PKS) auf der Ebene von Protein-Protein-Interaktionen und in ein Mitglied der Familie der Oxygenasen, Schlüsselenzyme für die strukturelle und chemische Feinjustierung von Naturstoffen.