Regulation of the molecular chaperone BiP by its co-chaperones

Nickels, Christina Utta

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Original title:: Regulation of the molecular chaperone BiP by its co-chaperones
Translated title:: Regulierung des Chaperones BiP durch seine Co-Chaperone
Author:: Nickels, Christina Utta
Year:: 2019
Document type:: Dissertation
Faculty/School:: Fakultät für Chemie
Advisor:: Buchner, Johannes (Prof. Dr)
Referee:: Buchner, Johannes (Prof. Dr); Feige, Matthias J. (Prof. Dr.)
Language:: en
Subject group:: CHE Chemie
TUM classification:: CHE 800d; CIT 900d
Abstract:: BiP, the mammalian Hsp70 chaperone in the ER, has a function in protein homeostasis and in the cellular stress response. The ATP-dependent chaperone cycle of BiP is regulated by co-chaperones. In this thesis, the co-chaperones ERdj3 and Bap were investigated. The purified proteins were characterized with regard to their stability, structure and functionality.
Translated abstract:: Das Hsp70 Chaperon BiP aus dem ER spielt eine entscheidende Rolle in der Proteinhomöostase und der Stressantwort der Zelle. Der ATP abhängige Zyklus von BiP wird von verschiedenen Co-Chaperonen reguliert. In dieser Doktorarbeit wurden das Co-Chaperone ERdj3 undder Nukleotidaustauschfaktor Bap genauer untersucht. Die gereinigten Proteine wurden hinsichtlich ihrer Stabilität, Struktur und Funktionalität untersucht.
WWW:: https://mediatum.ub.tum.de/?id=1484487
Date of submission:: 29.04.2019
Oral examination:: 17.06.2019
File size:: 7017077 bytes
Pages:: 134
Urn (citeable URL):: https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20190617-1484487-1-0
Last change:: 09.07.2019
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