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- Titel:
The Influence of Pubertal Development on Autoantibody Appearance and Progression to Type 1 Diabetes in the TEDDY Study.
- Dokumenttyp:
- Journal Article
- Autor(en):
- Warncke, Katharina; Tamura, Roy; Schatz, Desmond A; Veijola, Riitta; Steck, Andrea K; Akolkar, Beena; Hagopian, William; Krischer, Jeffrey P; Lernmark, Åke; Rewers, Marian J; Toppari, Jorma; McIndoe, Richard; Ziegler, Anette-G; Vehik, Kendra; Haller, Michael J; Elding Larsson, Helena
- Abstract:
- CONTEXT: The 2 peaks of type 1 diabetes incidence occur during early childhood and puberty. OBJECTIVE: We sought to better understand the relationship between puberty, islet autoimmunity, and type 1 diabetes. METHODS: The relationships between puberty, islet autoimmunity, and progression to type 1 diabetes were investigated prospectively in children followed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Onset of puberty was determined by subject self-assessment of Tanner stages. Associations between speed of pubertal progression, pubertal growth, weight gain, homeostasis model assessment of insulin resistance (HOMA-IR), islet autoimmunity, and progression to type 1 diabetes were assessed. The influence of individual factors was analyzed using Cox proportional hazard ratios. RESULTS: Out of 5677 children who were still in the study at age 8 years, 95% reported at least 1 Tanner Stage score and were included in the study. Children at puberty (Tanner Stage ≥2) had a lower risk (HR 0.65, 95% CI 0.45-0.93; P = .019) for incident autoimmunity than prepubertal children (Tanner Stage 1). An increase of body mass index Z-score was associated with a higher risk (HR 2.88, 95% CI 1.61-5.15; P < .001) of incident insulin autoantibodies. In children with multiple autoantibodies, neither HOMA-IR nor rate of progression to Tanner Stage 4 were associated with progression to type 1 diabetes. CONCLUSION: Rapid weight gain during puberty is associated with development of islet autoimmunity. Puberty itself had no significant influence on the appearance of autoantibodies or type 1 diabetes. Further studies are needed to better understand the underlying mechanisms.
- Zeitschriftentitel:
- J Endocr Soc
- Jahr:
- 2024
- Band / Volume:
- 8
- Heft / Issue:
- 7
- Volltext / DOI:
- doi:10.1210/jendso/bvae103
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/38867880
- Print-ISSN:
- 2472-1972
- TUM Einrichtung:
- Klinik und Poliklinik für Kinder- und Jugendmedizin (Prof. Hauer)
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