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- Titel:
T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.
- Dokumenttyp:
- Journal Article
- Autor(en):
- Kedia, Shreeya; Ji, Hao; Feng, Ruoqing; Androvic, Peter; Spieth, Lena; Liu, Lu; Franz, Jonas; Zdiarstek, Hanna; Anderson, Katrin Perez; Kaboglu, Cem; Liu, Qian; Mattugini, Nicola; Cherif, Fatma; Prtvar, Danilo; Cantuti-Castelvetri, Ludovico; Liesz, Arthur; Schifferer, Martina; Stadelmann, Christine; Tahirovic, Sabina; Gokce, Ozgun; Simons, Mikael
- Abstract:
- Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer's disease remains uncertain, despite age being a major risk factor. Using a mouse model of Alzheimer's disease, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8+ T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, our data suggest that immune responses against myel... »
- Zeitschriftentitel:
- Nat Neurosci
- Jahr:
- 2024
- Band / Volume:
- 27
- Heft / Issue:
- 8
- Seitenangaben Beitrag:
- 1468-1474
- Volltext / DOI:
- doi:10.1038/s41593-024-01682-8
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/38937583
- Print-ISSN:
- 1097-6256
- TUM Einrichtung:
- 1367; 657; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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