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Titel:

Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease.

Dokumenttyp:
Journal Article
Autor(en):
Ziegler, Karin A; Ahles, Andrea; Dueck, Anne; Esfandyari, Dena; Pichler, Pauline; Weber, Karolin; Kotschi, Stefan; Bartelt, Alexander; Sinicina, Inga; Graw, Matthias; Leonhardt, Heinrich; Weckbach, Ludwig T; Massberg, Steffen; Schifferer, Martina; Simons, Mikael; Hoeher, Luciano; Luo, Jie; Ertürk, Ali; Schiattarella, Gabriele G; Sassi, Yassine; Misgeld, Thomas; Engelhardt, Stefan
Abstract:
Disruption of the physiologic sleep-wake cycle and low melatonin levels frequently accompany cardiac disease, yet the underlying mechanism has remained enigmatic. Immunostaining of sympathetic axons in optically cleared pineal glands from humans and mice with cardiac disease revealed their substantial denervation compared with controls. Spatial, single-cell, nuclear, and bulk RNA sequencing traced this defect back to the superior cervical ganglia (SCG), which responded to cardiac disease with ac...     »
Zeitschriftentitel:
Science
Jahr:
2023
Band / Volume:
381
Heft / Issue:
6655
Seitenangaben Beitrag:
285-290
Volltext / DOI:
doi:10.1126/science.abn6366
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37471539
Print-ISSN:
0036-8075
TUM Einrichtung:
606; 657; Institut für Pharmakologie und Toxikologie (Prof. Engelhardt); Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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