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Title:

Stroma AReactive Invasion Front Areas (SARIFA) proves prognostic relevance in gastric carcinoma and is based on a tumor-adipocyte interaction indicating an altered immune response.

Document type:
Journal Article; Comment
Author(s):
Grosser, Bianca; Heyer, Christian M; Austgen, Johannes; Sipos, Eva; Reitsam, Nic G; Hauser, Andreas; VanSchoiack, Alison; Kroeppler, David; Vlasenko, Dmytro; Probst, Andreas; Novotny, Alexander; Weichert, Wilko; Keller, Gisela; Schlesner, Matthias; Märkl, Bruno
Abstract:
BACKGROUND: Recently, we presented Stroma AReactive Invasion Front Areas (SARIFA) as a new histomorphologic negative prognostic biomarker in gastric cancer. It is defined as direct contact between tumor cells and fat cells. The aim of this study was to further elucidate the underlying genomic, transcriptional, and immunological mechanisms of the SARIFA phenomenon. METHODS: To address these questions, SARIFA was classified on H&E-stained; tissue sections of three cohorts: an external cohort (n = 489, progn...     »
Journal title abbreviation:
Gastric Cancer
Year:
2024
Journal volume:
27
Journal issue:
1
Pages contribution:
72-85
Fulltext / DOI:
doi:10.1007/s10120-023-01436-8
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37874427
Print-ISSN:
1436-3291
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.)
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