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Titel:

Tipping points in neurodegeneration.

Dokumenttyp:
Journal Article; Review; Research Support, Non-U.S. Gov't
Autor(en):
Simons, Mikael; Levin, Johannes; Dichgans, Martin
Abstract:
In Alzheimer's disease (AD), Aβ deposits form slowly, several decades before further pathological events trigger neurodegeneration and dementia. However, a substantial proportion of affected individuals remains non-demented despite AD pathology, raising questions about the underlying factors that determine the transition to clinical disease. Here, we emphasize the critical function of resilience and resistance factors, which we extend beyond the concept of cognitive reserve to include the glial,...     »
Zeitschriftentitel:
Neuron
Jahr:
2023
Band / Volume:
111
Heft / Issue:
19
Seitenangaben Beitrag:
2954-2968
Volltext / DOI:
doi:10.1016/j.neuron.2023.05.031
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37385247
Print-ISSN:
0896-6273
TUM Einrichtung:
617; 657; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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