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Title:

Remyelination by surviving oligodendrocytes is inefficient in the inflamed mammalian cortex.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Mezydlo, Aleksandra; Treiber, Nils; Ullrich Gavilanes, Emily Melisa; Eichenseer, Katharina; Ancău, Mihai; Wens, Adinda; Ares Carral, Carla; Schifferer, Martina; Snaidero, Nicolas; Misgeld, Thomas; Kerschensteiner, Martin
Abstract:
In multiple sclerosis, an inflammatory attack results in myelin loss, which can be partially reversed by remyelination. Recent studies suggest that mature oligodendrocytes could contribute to remyelination by generating new myelin. Here, we show that in a mouse model of cortical multiple sclerosis pathology, surviving oligodendrocytes can indeed extend new proximal processes but rarely generate new myelin internodes. Furthermore, drugs that boost myelin recovery by targeting oligodendrocyte prec...     »
Journal title abbreviation:
Neuron
Year:
2023
Journal volume:
111
Journal issue:
11
Pages contribution:
1748-1759.e8
Fulltext / DOI:
doi:10.1016/j.neuron.2023.03.031
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37071991
Print-ISSN:
0896-6273
TUM Institution:
Klinik und Poliklinik für Neurologie (Prof. Hemmer); Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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