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Title:

Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Groh, Janos; Abdelwahab, Tassnim; Kattimani, Yogita; Hörner, Michaela; Loserth, Silke; Gudi, Viktoria; Adalbert, Robert; Imdahl, Fabian; Saliba, Antoine-Emmanuel; Coleman, Michael; Stangel, Martin; Simons, Mikael; Martini, Rudolf
Abstract:
Axon degeneration and functional decline in myelin diseases are often attributed to loss of myelin but their relation is not fully understood. Perturbed myelinating glia can instigate chronic neuroinflammation and contribute to demyelination and axonal damage. Here we study mice with distinct defects in the proteolipid protein 1 gene that develop axonal damage which is driven by cytotoxic T cells targeting myelinating oligodendrocytes. We show that persistent ensheathment with perturbed myelin p...     »
Journal title abbreviation:
Nat Commun
Year:
2023
Journal volume:
14
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-023-42570-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37903797
Print-ISSN:
2041-1723
TUM Institution:
657; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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