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Title:

Spatial Transcriptomics-correlated Electron Microscopy maps transcriptional and ultrastructural responses to brain injury.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Androvic, Peter; Schifferer, Martina; Perez Anderson, Katrin; Cantuti-Castelvetri, Ludovico; Jiang, Hanyi; Ji, Hao; Liu, Lu; Gouna, Garyfallia; Berghoff, Stefan A; Besson-Girard, Simon; Knoferle, Johanna; Simons, Mikael; Gokce, Ozgun
Abstract:
Understanding the complexity of cellular function within a tissue necessitates the combination of multiple phenotypic readouts. Here, we developed a method that links spatially-resolved gene expression of single cells with their ultrastructural morphology by integrating multiplexed error-robust fluorescence in situ hybridization (MERFISH) and large area volume electron microscopy (EM) on adjacent tissue sections. Using this method, we characterized in situ ultrastructural and transcriptional res...     »
Journal title abbreviation:
Nat Commun
Year:
2023
Journal volume:
14
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-023-39447-9
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37433806
Print-ISSN:
2041-1723
TUM Institution:
657; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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