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Title:

Tipping points in neurodegeneration.

Document type:
Journal Article; Review; Research Support, Non-U.S. Gov't
Author(s):
Simons, Mikael; Levin, Johannes; Dichgans, Martin
Abstract:
In Alzheimer's disease (AD), Aβ deposits form slowly, several decades before further pathological events trigger neurodegeneration and dementia. However, a substantial proportion of affected individuals remains non-demented despite AD pathology, raising questions about the underlying factors that determine the transition to clinical disease. Here, we emphasize the critical function of resilience and resistance factors, which we extend beyond the concept of cognitive reserve to include the glial,...     »
Journal title abbreviation:
Neuron
Year:
2023
Journal volume:
111
Journal issue:
19
Pages contribution:
2954-2968
Fulltext / DOI:
doi:10.1016/j.neuron.2023.05.031
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37385247
Print-ISSN:
0896-6273
TUM Institution:
617; 657; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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