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Titel:

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease.

Dokumenttyp:
Journal Article
Autor(en):
Depp, Constanze; Sun, Ting; Sasmita, Andrew Octavian; Spieth, Lena; Berghoff, Stefan A; Nazarenko, Taisiia; Overhoff, Katharina; Steixner-Kumar, Agnes A; Subramanian, Swati; Arinrad, Sahab; Ruhwedel, Torben; Möbius, Wiebke; Göbbels, Sandra; Saher, Gesine; Werner, Hauke B; Damkou, Alkmini; Zampar, Silvia; Wirths, Oliver; Thalmann, Maik; Simons, Mikael; Saito, Takashi; Saido, Takaomi; Krueger-Burg, Dilja; Kawaguchi, Riki; Willem, Michael; Haass, Christian; Geschwind, Daniel; Ehrenreich, Hannelore;...     »
Abstract:
The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing affects oligodendrocytes and the structural integrity of myelin sheaths1, the latter of which is associated with secondary neuroinflammation2,3. As oligodendrocytes support axonal energy metabolism and neuronal health4-7, we hypothesized that loss of myelin integrity could be an upstream risk factor for neurona...     »
Zeitschriftentitel:
Nature
Jahr:
2023
Band / Volume:
618
Heft / Issue:
7964
Seitenangaben Beitrag:
349-357
Volltext / DOI:
doi:10.1038/s41586-023-06120-6
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37258678
Print-ISSN:
0028-0836
TUM Einrichtung:
657; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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