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Titel:

Novel Tumor Organoid-Based Mouse Model to Study Image Guided Radiation Therapy of Rectal Cancer After Noninvasive and Precise Endoscopic Implantation.

Dokumenttyp:
Journal Article
Autor(en):
Felchle, Hannah; Brunner, Valentina; Groll, Tanja; Walther, Caroline N; Nefzger, Sophie M; Zaurito, Antonio E; Silva, Miguel G; Gissibl, Julia; Topping, Geoffrey J; Lansink Rotgerink, Laura; Saur, Dieter; Steiger, Katja; Combs, Stephanie E; Tschurtschenthaler, Markus; Fischer, Julius C
Abstract:
PURPOSE: Preoperative (neoadjuvant) radiation therapy (RT) is an essential part of multimodal rectal cancer therapy. Recently, total neoadjuvant therapy (TNT), which combines simultaneous radiochemotherapy with additional courses of chemotherapy, has emerged as an effective approach. TNT achieves a pathologic complete remission in approximately 30% of resected patients, opening avenues for treatment strategies that avoid radical organ resection. Furthermore, recent studies have demonstrated that...     »
Zeitschriftentitel:
Int J Radiat Oncol Biol Phys
Jahr:
2024
Band / Volume:
118
Heft / Issue:
4
Seitenangaben Beitrag:
1094-1104
Volltext / DOI:
doi:10.1016/j.ijrobp.2023.10.008
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37875245
Print-ISSN:
0360-3016
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Klinik und Poliklinik für Nuklearmedizin (Prof. Weber); Klinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs)
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