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Title:

Expression of Nectin-4 in Chromophobe Renal Cell Carcinoma in a Multicenter Cohort: Early Prognostic and Therapeutic Considerations.

Document type:
Journal Article; Multicenter Study
Author(s):
Mikuteit, Marie; Zschäbitz, Stefanie; Autenrieth, Michael; Weichert, Wilko; Hartmann, Arndt; Steffens, Sandra; Erlmeier, Franziska
Abstract:
INTRODUCTION: Nectin-4 is a member of the nectin family and a calcium-independent immunoglobulin-like transmembrane protein that contributes to tumor growth and angiogenesis in malignant tumors. A nectin-4-directed antibody drug conjugate, enfortumab vedotin-ejf, has recently been approved for treatment in urothelial cancer and is currently under investigation in other tumor entities such as breast, lung, and prostate cancer. In non-clear cell renal cell carcinoma (RCC), vascular endothelial gro...     »
Journal title abbreviation:
Oncology
Year:
2024
Journal volume:
102
Journal issue:
6
Pages contribution:
503-509
Fulltext / DOI:
doi:10.1159/000535473
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/38043528
Print-ISSN:
0030-2414
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Klinik und Poliklinik für Urologie (Prof. Gschwend)
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