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Titel:

Single-cell fate mapping reveals widespread clonal ignorance of low-affinity T cells exposed to systemic infection.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Leube, Justin; Mühlbauer, Anton; Andrä, Immanuel; Biggel, Madleen; Busch, Dirk H; Kretschmer, Lorenz; Buchholz, Veit R
Abstract:
T cell ignorance is a specific form of immunological tolerance. It describes the maintenance of naivety in antigen-specific T cells in vivo despite the presence of their target antigen. It is thought to mainly play a role during the steady state, when self-antigens are presented in absence of costimulatory signals and at low density or to T cells of low affinity. In how far antigen-specific T cells can also remain clonally ignorant to foreign antigens, presented in the inflammatory context of sy...     »
Zeitschriftentitel:
Eur J Immunol
Jahr:
2023
Band / Volume:
53
Heft / Issue:
3
Volltext / DOI:
doi:10.1002/eji.202250009
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36458456
Print-ISSN:
0014-2980
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene (Prof. Busch)
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