Pancreatic Ductal Adenocarcinoma (PDAC), a form of pancreatic cancer, is highly lethal.
To study morphogenesis and understand disease progression, organoids - in vitro 3D cell cultures that display features of an organ of interest - are a highly promising tool.
By embedding single murine PDAC-derived cells in collagen, we generate complex 3D organoids that display branches, buds, and a lumen connecting the network, closely resembling the architectures of the exocrine pancreas and of its lesions.
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Pancreatic Ductal Adenocarcinoma (PDAC), a form of pancreatic cancer, is highly lethal.
To study morphogenesis and understand disease progression, organoids - in vitro 3D cell cultures that display features of an organ of interest - are a highly promising tool.
By embedding single murine PDAC-derived cells in collagen, we generate complex 3D organoids that display branches, buds, and a lumen connecting the network, closely resembling the architectures of the exocrine pancreas and of its lesions....
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