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Titel:

Bacterial outer membrane vesicles as cationic dye carriers for optoacoustics-guided phototherapy of cancer

Dokumenttyp:
Article
Autor(en):
Liu, Nian; Gujrati, Vipul; Werner, Juan Pablo Fuenzalida; Mishra, Kanuj; Anzenhofer, Pia; Stiel, Andre C. C.; Mettenleiter, Gabriele; Feuchtinger, Annette; Walch, Axel; Ntziachristos, Vasilis
Abstract:
BackgroundCationic dyes are widely used as biomarkers for optical imaging. However, most of these are hydrophobic and cannot be employed in vivo without chemical conjugation or modification. Herein, we report for the first time the use of bacterial outer membrane vesicles (OMVs) as nanocarriers of cationic dyes for cancer theranostics.ResultsWe demonstrate that cationic dyes (IR780, Cy7, and Cy7.5) form stable complexes with negatively charged bacterial-OMVs, improving the dyes' in vivo circulat...     »
Zeitschriftentitel:
Cancer Nanotechnology
Zeitschriftentitel:
Cancer Nanotechnol.
Jahr:
2023
Band / Volume:
14
Heft / Issue:
1
Volltext / DOI:
doi:10.1186/s12645-023-00191-w
WWW:
https://cancer-nano.biomedcentral.com/articles/10.1186/s12645-023-00191-w
Print-ISSN:
1868-6958
TUM Einrichtung:
Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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