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Title:

Fast 3D Optoacoustic Mesoscopy of Neuromelanin Through Entire Human Midbrain Organoids at Single-Cell Resolution

Document type:
Zeitschriftenaufsatz
Author(s):
Englert, Ludwig; Lacalle-Aurioles, Maria; Mohamed, Nguyen-Vi; Lepine, Paula; Mathur, Meghna; Ntziachristos, Vasilis; Durcan, Thomas M.; Aguirre, Juan
Abstract:
Parkinson's disease is a devastating neurodegenerative disorder characterized by loss of neuromelanin-containing dopaminergic neurons. Novel 3D culture systems like human midbrain-like organoids (hMOs) enable new research avenues for patient-specific therapies, but cannot reach their full potential unless rapid optical imaging of entire organoids is enabled. Currently, hMOs have to undergo tissue clearing processes before imaging to overcome light scattering. Since tissue clearing is a lengthy c...     »
Journal title:
Laser & Photonics Reviews
Journal title abbreviation:
Laser Photon Rev
Year:
2023
Journal volume:
17
Journal issue:
8
Fulltext / DOI:
doi:10.1002/lpor.202300443
WWW:
https://onlinelibrary.wiley.com/doi/10.1002/lpor.202300443
Print-ISSN:
1863-8880
TUM Institution:
Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
CC license:
by, http://creativecommons.org/licenses/by/4.0
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