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Title:

Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kulaj, Konxhe; Harger, Alexandra; Bauer, Michaela; Caliskan, Özüm S; Gupta, Tilak Kumar; Chiang, Dapi Menglin; Milbank, Edward; Reber, Josefine; Karlas, Angelos; Kotzbeck, Petra; Sailer, David N; Volta, Francesco; Lutter, Dominik; Prakash, Sneha; Merl-Pham, Juliane; Ntziachristos, Vasilis; Hauner, Hans; Pfaffl, Michael W; Tschöp, Matthias H; Müller, Timo D; Hauck, Stefanie M; Engel, Benjamin D; Gerdes, Jantje M; Pfluger, Paul T; Krahmer, Natalie; Stemmer, Kerstin
Abstract:
Adipocyte-derived extracellular vesicles (AdEVs) are membranous nanoparticles that convey communication from adipose tissue to other organs. Here, to delineate their role as messengers with glucoregulatory nature, we paired fluorescence AdEV-tracing and SILAC-labeling with (phospho)proteomics, and revealed that AdEVs transfer functional insulinotropic protein cargo into pancreatic β-cells. Upon transfer, AdEV proteins were subjects for phosphorylation, augmented insulinotropic GPCR/cAMP/PKA sign...     »
Journal title:
Nature Communications
Journal title abbreviation:
Nat Commun
Year:
2023
Journal volume:
14
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-023-36148-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36759608
WWW:
https://www.nature.com/articles/s41467-023-36148-1
Print-ISSN:
2041-1723
TUM Institution:
Klinik für Ernährungsmedizin (Prof. Hauner); Klinik und Poliklinik für Vaskuläre und Endovaskuläre Chirurgie (Prof. Eckstein); Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos); Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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